… Clearance and midazolam dose in neonates was also predicted … of midazolam clearance in
preterm neonates and term … 0.1 mg/kg midazolam given by intravenous (IV) infusion over 30 …

… A dose of 0.1 mg/kg midazolam was simulated as oral administration or as a 30-minute
intravenous infusion in 37 preterm neonates with the same patient characteristics as the …

… the PK of oral and IV midazolam. Inclusion of IIV for clearance, volume of distribution, and …
bioavailability 3 than found in our patients, and vice versa for preterm neonates. Statistically …

… to predict the disposition of IV Midazolam in preterm neonates of different gestational ages,
… Clinical pharmacology and therapeutic drug monitoring in neonates and children. Pediatr. …

… individual differences exist in pharmacokinetic parameters for intravenous midazolam. …
in preterm neonates compared with that in older infants and children. Midazolam undergoes …

… preterm infants were undertaken for tracheal intubation following the use of atropine associated
to either midazolam … pain was assessed using premature infant pain profile (PIPP) score. …

… solution is available in most European countries, it is usual to administer midazolam
intravenous solution orally, however it exhibits a strong bitterness, which can cause children to spit …

… midazolam’s pharmacokinetics and pharmacodynamics, … A single dose of midazolam
co-administered with oral … the midazolam AUC 0–∞ by 219% after intravenous midazolam …

… Neonatal pharmacokinetics and pharmacodynamics exhibit considerable … midazolam
infusion as sedation for mechanical ventilation in 46 preterm infants found that while midazolam …

… our intravenous PBPK model that extended the predicted age to preterm. The simulation
results of the PD model showed that when the free concentrations of midazolam ranged from …